PROJECTS

Precision Strategies for Novel and Exploratory Therapeutics

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RBRAIN - MDMA

We know little about exactly how MDMA – ‘ecstasy’ – impacts the human brain in real time and how brain changes relate to the experience of MDMA.  In this study we acquire neuroimaging brain scans immediately following doses of MDMA versus placebo, in a novel mechanistic trial design with healthy individuals. We also acquire detailed information about the individual experiences of each participant so as to connect brain changes to experience. Data from this study is vital to discovering how MDMA works in a more precise way and will inform its safe and personalized therapeutic use in future trials.

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RBRAIN - KETAMINE

Although ketamine has promise as a therapeutic when used at sub-anesthetic doses, we know little about exactly how it impacts the human brain in real time.  In this study we acquire neuroimaging brain scans immediately following infusions of ketamine versus placebo, in a novel mechanistic trial design with healthy individuals. We also acquire detailed information about the individual experiences of each participant so as to connect brain changes to experience. Data from this study is vital to discovering how ketamine works in a more precise way and will inform its safe and personalized therapeutic use in future trials.