RBRAIN - KETAMINE

Although ketamine has promise as a therapeutic when used at sub-anesthetic doses, we know little about exactly how it impacts the human brain in real-time.  In this study, we acquire neuroimaging brain scans immediately following infusions of ketamine versus placebo, in a novel mechanistic trial design with healthy individuals. We also acquire detailed information about the individual experiences of each participant so as to connect brain changes to experience. Data from this study is vital to discovering how ketamine works in a more precise way and will inform its safe and personalized therapeutic use in future trials.