Helen Mayberg MD, a neurologist, is Professor of Neurology, Neurosurgery, Psychiatry and Neuroscience, and the Mount Sinai Professor in Neurotherapeutics at the Icahn School of Medicine where she serves as Founding Director of the Nash Family Center for Advanced Circuit Therapeutics. Recognized for her neuroimaging studies of brain circuits in depression and their translation to the development of deep brain stimulation as a novel therapeutic for treatment resistant patients, she now leads a patient-focused transdisciplinary research team with the shared mission to advance precision surgical treatments for complex neuropsychiatric disorders.  Past studies worked to develop and test imaging-based biomarkers and algorithms to optimize treatment selection for individual patients.at all stages of illness. Current studies focus on refinement of DBS for TRD utilizing a range of mechanism-of-action and predictive biomarker strategies including bidirectional translational studies using animal models.

Complementary strategies using multimodal imaging, chronic intracranial monitoring, computer vision and machine learning are being developed to detect more subtle changes in core depression-relevant behaviors relevant to DBS optimization, but that can also be generalized to treatments at all stages of illness. Dr. Mayberg is a member of the US National Academy of Sciences, the National Academy of Medicine, the National Academy of Inventors and the American Academy of Arts and Sciences and participates in a wide variety of advisory and scientific activities across multiple fields in neuroscience.