ACE-D: Accelerating Cognition-guided Signatures to Enhance translation in Depression
Personalized Treatment Study
(8-week Treatment Study with Brain Imaging)
Overview
Dr. Leanne Williams and her team have identified a unique cognitive biotype of depression characterized by difficulty with concentration, focus, and decision making. This treatment study investigates whether people with this cognitive biotype could benefit from a tailored depression treatment that includes guanfacine, a medication that may improve cognitive control. Participants will complete computer-based tasks and noninvasive brain scans to assess their cognitive signature (an individual’s thinking style) and then be randomly assigned to one of two treatment groups. Please see Stanford press release for more information.
Goals
Many people with depression struggle with “brain fog,” or difficulty thinking clearly. However, traditional depression treatments typically do not address these difficulties. If a “precision medicine” approach — like choosing a depression treatment based on an individual’s cognitive profile — is effective, clinicians could use this method to help tailor treatment for patients with depression.
Sign Up to Participate
Our study is currently recruiting adults between the ages of 18 and 60 who are experiencing depression and are able to travel to Stanford University.
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This study is a clinical trial which includes 3 study visits at Stanford, fMRI brain scans, and online computerized assessments and surveys.
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If you are interested in participating in the study, please complete the following online screening survey:
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Once we receive your completed screening survey, we’ll review it and reach out as soon as possible if you appear to be eligible. Thank you for your interest in our research!
Meet the Team
Olusola Ajilore, MD, PhD
Principal Investigator, UIC
Laura Hack, MD, PhD
Co-Investigator, Stanford
Leanne Williams, PhD
Principal Investigator, Stanford
Jun Ma, MD, PhD
Principal Investigator, UIC
Trevor Hastie, PhD
Co-investigator, Stanford
Booil Jo, PhD
Co-Investigator, Stanford
Alex Leow, MD, PhD
Co-Investigator, Stanford
Ruth O'Hara, PhD
Co-Investigator, Stanford
Alan Schatzberg, PhD
Co-investigator, Stanford
Peter Van Rossel, MD, PhD
Co-Investigator, Stanford
Lara Foland-Ross, PhD
Co-Investigator, Stanford
Teddy Akiki, MD
Co-Investigator, Stanford
Erica Ma, MS, PA-c
Physician Assistant, Stanford
Rachel Hilton, PhD-c, PMHNP-BC
Nurse Practitioner, Stanford
Leyla Boyar
Clinical Res. Coordinator, Stanford
Isabelle Wydler
Clinical Res. Coordinator, Stanford
Andrea Ellsay
Precision Psychiatry Research Engineer - Neuroimaging Lead, Stanford
Booil Jo, PhD
Precision Psychiatry Data Analyst - Clinical and Behavioral Data Lead, Stanford
Rio Hundley
Clinical Research Coordinator Associate, Stanford
Conner Oberhauser
Clinical Research Coordinator Associate, Stanford
Liangfang Li, PhD
Postdoctoral Fellow, Stanford
Jeesung Ahn, PhD
Postdoctoral Fellow Stanford
Daniella Evangelista
Clinical Research Coordinator Associate, Stanford
Funding
ACE-D is funded through an NIH initiative, Individually Measured Phenotypes to Advance Computational Translation in Mental Health (IMPACT-MH).
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Grant: U01MH136062