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Stanford Center for Precision
Mental Health and Wellness
DATASETS
Over the years, the PMHW has built an extensive dataset for mental health research. Our database comprises of data collected across clinical and healthy populations using several different modalities.
Some highlights of the data collected by the PMHW include:
- More than 6600 brain scans
- More than 5200 standardized cognitive tests
- More than 2700 data on genetic single nucleotide polymorphisms
- More than 7000 questionnaires pertaining to various aspects of
mental health & wellbeing
- More than 1800 free-form text descriptions of subjective
experiences of mental illness
We always welcome proposals from scientists who would like to access this data for their research and for collaborations. Also, we have many opportunities for students or volunteers that involve analyzing data or helping us maintain and quality check the database.
Due to increased volume of requests, we are temporarily limiting data sharing requests.
If you are interested in working with our data, please contact us with a brief paper proposal at pmhw_admin@stanford.edu.
Stanford BRAINnet:
Stanford Center for Precision Mental Health and Wellness standardized and annotated data to foster reproducible collaborative research.
Our datasets are available to researchers for non-commercial research purposes and to affiliates of our PMHW Corporate Members program for special projects.
HCP-DES
Patient populations: Depression, GAD
The Human Connectome Project for Disordered Emotional States (HCP-DES) dataset includes baseline and follow-up measures of Research Domain Criteria constructs relevant to depression and anxiety: loss and acute threat within the Negative Valence System domain; reward valuation and responsiveness within the Positive Valence System domain; and working memory and cognitive control within the Cognitive System domain.
Data were collected from 250 unmedicated clinical participants experiencing disordered emotional states and 50 healthy controls. Symptoms of clinical participants were followed-up every three months for a year.
Key references
1. Tozzi, L. et al. The human connectome project for disordered emotional states: Protocol and rationale for a research domain criteria study of brain connectivity in young adult anxiety and depression. NeuroImage 214, 116715 (2020).
Demographics, symptoms, structural MRI, task fMRI, resting fMRI, diffusion MRI, general and social cognition
Follow up over 12 months
Available from:
https://www.humanconnectome.org/study/crhd-mapping-connectomes-disordered-mental-states
RAD
Patient populations: Depression, GAD
The Research domain criteria Anxiety and Depression (RAD) dataset includes baseline and follow-up measures from patients on the trans-diagnostic spectrum of depression and anxiety.
Data were collected in 388 clinical participants. Symptoms were followed up at three months.
Key references
1. Williams, L. M. et al. Developing a clinical translational neuroscience taxonomy for anxiety and mood disorder: protocol for the baseline-follow up Research domain criteria Anxiety and Depression ("RAD") project. BMC Psychiatry 16, (2016).
Demographics, symptoms, structural MRI, task fMRI, resting fMRI, diffusion MRI, general and social cognition
Follow up over 12 months
Available from:
https://nda.nih.gov/edit_collection.html?id=2100
iSPOT-D
Patient populations: Depression, GAD
The International Study to Predict Optimised Treatment in Depression (iSPOT-D) dataset includes baseline and post-treatment data from a precision medicine trial of major depression.
Data were collected from 1,008 unmedicated clinical participants with major depressive disorder and 336 matched healthy controls. Clinical participants were then randomly assigned to treatment with 3 first-line antidepressants. Both clinical participants and controls were followed-up at weeks 12, 16, 24 and 52. MRI data was acquired from 20% of clinical participants and healthy controls at baseline and after two months of antidepressant treatment.
Key references
1. Williams, L. M. et al. International Study to Predict Optimized Treatment for Depression (iSPOT-D), a randomized clinical trial: rationale and protocol. Trials 12, 4 (2011).
2. Grieve, S. M. et al. Brain imaging predictors and the international study to predict optimized treatment for depression: study protocol for a randomized controlled trial. Trials 14, 224 (2023).
Demographics, symptoms, personality, resting EEG, task EEG, longitudinal structural MRI, longitudinal task fMRI, longitudinal diffusion MRI, general and social cognition, genetics (SNP)
Pre-post intervention
Available from:
https://redcap.link/pmhw_analysis_request
ENGAGE
Patient populations: Depression, Obesity
A precision medicine randomized controlled trial of 108 patients depression and comorbid obesity. Patients were randomized to a behavioral problem solving intervention or treatment as usual and assessed at 5 time points over 2 years using functional MRI, general and social emotional cognition, symptoms and wearable measures. The imaging and cognitive measures were standardized with those used in iSPOT-D and all of the above studies.
Key references
1. Williams LM, Pines A, Goldstein-Piekarski AN, Rosas LG, Kullar M, Sacchet MD, Gevaert O, Bailenson J, Lavori PW, Dagum P, Wandell B, Correa C, Greenleaf W, Suppes T, Perry LM, Smyth JM, Lewis MA, Venditti EM, Snowden M, Simmons JM, Ma J. The ENGAGE study: Integrating neuroimaging, virtual reality and smartphone sensing to understand self-regulation for managing depression and obesity in a precision medicine model. Behav Res Ther. 2018 Feb;101:58-70. doi: 10.1016/j.brat.2017.09.012. Epub 2017 Oct 7. PMID: 29074231; PMCID: PMC8109191.
Demographics, symptoms, longitudinal resting fMRI, longitudinal task fMRI, longitudinal general and social cognition, wearables
Pre-post intervention
Available from:
https://redcap.link/pmhw_analysis_request
Family
The Family dataset includes baseline and follow-up data from first-degree relatives of participants with a history of mood disorders.
Date were collected using identical protocols to iSPOT-D in 101 adult sons and daughters of participants with a history of major depressive disorder and accompanying anxiety disorders. Participants did not meet criteria for a mental health diagnosis at baseline. They were followed up over 12 months and 20% of the sample met criteria for major depressive disorder at follow-up.
Key references
1. Watters, A. J., Gotlib, I. H., A. W. F., Boyce, P. M. & Williams, L. M. Using multiple methods to characterize the phenotype of individuals with a family history of major depressive disorder. J Affect Disord 150, 474–480 (2013).
Demographics, symptoms, personality, resting EEG, task EEG, structural MRI, task fMRI, diffusion MRI, general and social cognition, genetics (SNP)
Follow up over 24 months
Available from:
https://redcap.link/pmhw_analysis_request
TWIN-E
TWIN-10
The TWIN-E dataset includes baseline and follow-up data from a large cohort of healthy twins.
Date were collected using identical protocols to iSPOT-D in 1,600 from a national cohort of healthy twins, both identical and fraternal. Imaging data was collected from 10% of them. Twins were followed up over 12 months in the initial longitudinal wave of the study. In a second wave, they are being re-assessed after 10 years.
Key references
1. Gatt, J. M. et al. The TWIN-E Project in Emotional Wellbeing: Study Protocol and Preliminary Heritability Results Across Four MRI and DTI Measures. Twin Research and Human Genetics 15, 419–441 (2012).
2. Park, H. R. P., Williams, L. M., Turner, R. M. & Gatt, J. M. TWIN-10: protocol for a 10-year longitudinal twin study of the neuroscience of mental well-being and resilience. BMJ Open 12, e058918 (2022).
Demographics, symptoms, personality, resting EEG, task EEG, structural MRI, task fMRI, diffusion MRI, general and social cognition, genetics (SNP)
Follow up data
Available from:
https://redcap.link/pmhw_analysis_request
ACTION
Patient populations: ADHD
A randomized controlled trial investigation of a non-stimulant in attention deficit hyperactivity disorder (ACTION).
Key references
1. Tsang, T.W., Kohn, M.R., Hermens, D.F. et al. A randomized controlled trial investigation of a non-stimulant in attention deficit hyperactivity disorder (ACTION): Rationale and design. Trials 12, 77 (2011).
https://doi.org/10.1186/1745-6215-12-77
Demographics, symptoms, personality, resting EEG, task EEG, general and social cognition.
Pre-post intervention
Available from:
https://redcap.link/pmhw_analysis_request
BRAINnet
Original
Clinical,
adult
Patient populations: Major Depression, Psychosis, Panic disorder, PTSD
Acquired 2006-2008
337 clinical adults with 315 matched healthy subjects
Normed to a matched group of 1,317 healthy participants with an age range of 6 to 92 years.
Key references
1. Norms:
Williams, L.M. A platform for standardized online delivered, clinically applicable neurocognitive assessment: WebNeuro. Biorxiv. doi: https://doi.org/10.1101/2023.08.28.553107
Demographics, symptoms (DASS), resting EEG, task EEG, general and social cognition.
Available from:
https://redcap.link/pmhw_analysis_request
BRAINnet
Original
Clinical,
minors
Patient populations: ADHD, First episode/early onset psychosis, anorexia nervosa, functional neurological disorder
Acquired 2006-2008
465 clinical minors with 485 matched healthy subjects
Normed to a matched group of 1,317 healthy participants with an age range of 6 to 92 years.
Key references
1. Hilton, R.A., Tozzi, L., Nesamoney, S. et al. Transdiagnostic neurocognitive dysfunction in children and adolescents with mental illness. Nat. Mental Health 2, 299–309 (2024). https://doi.org/10.1038/s44220-023-00199-6
2. Norms:
Williams, L.M. A platform for standardized online delivered, clinically applicable neurocognitive assessment: WebNeuro. Biorxiv. doi: https://doi.org/10.1101/2023.08.28.553107
Demographics, symptoms (DASS), resting EEG, task EEG, general and social cognition.
(note: symptom ratings were validated for child version)
Available from:
https://redcap.link/pmhw_analysis_request
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